冠状病毒感染对肺功能测试和生活质量的影响
Ming Ren Toh1,2, Ying Rachel Teo3, Li Choo Ruby Poh3
1Department of Internal Medicine, Sengkang General Hospital, Singapore, Singapore. mingren.toh@mohh.com.sg.
Scientific reports
|October 12, 2023
概括
对于COVID-19幸存者的肺功能测试 (PFT) 建议最早在感染后6个月进行. 患有正常PFT的患者不需要重复测试,而异常结果则需要每6个月进行一次随访.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 临界护理医学 临界护理医学
背景情况:
- 已知COVID-19后的肺部后果,需要有效的管理策略.
- 幸存者诊所在监测COVID-19幸存者方面发挥着至关重要的作用.
- 间歇性肺功能测试 (PFTs) 的最佳时间和患者选择仍然不清楚.
研究的目的:
- 为了确定哪些COVID-19幸存者需要间隔PFTs.
- 确定在COVID-19后执行间隔PFT的适当时间.
- 调查PFTs在评估肺复苏中的有用性.
主要方法:
- 一项前性队列研究涉及46名COVID-19幸存者进行了12个月的跟踪.
- 间隔PFT和简单-36 (SF-36) 健康调查在6,9和12个月进行.
- 胸部计算机断层扫描 (CT) 为患有PFT缺陷的患者提供.
主要成果:
- 37%的患者患有严重/危急疾病,更有可能出现DLCO缺陷 (59%对17%,p=0.005) 和较低的SF-36分数.
- 在PFT和SF-36得分的差异在6个月间隔时最明显.
- DLCO缺陷与年龄较大,炎症标志物升高以及胸部X射线透的情况相关. 肥胖和未诊断的肺部疾病导致39%的PFT异常.
结论:
- 间隔PFT可以在COVID-19后6个月就开始.
- 正常的PFT结果表明不需要重复测试;异常结果需要每6个月进行一次后续PFT,直到解决.
- 持续的PFT异常需要考虑非COVID-19差异诊断.
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