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在多囊性卵巢综合征中血内膜的改变

Ke Yang¹, Xiaoqing Zhang¹, Wenwu Gui²

¹Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, School of Laboratory Medicine, Chongqing Medical University, Chongqing, China.

Reproductive sciences (Thousand Oaks, Calif.)

|October 12, 2023

概括

多囊卵巢综合征 (PCOS) 与改变的肠道微生物群有关. 这项研究在PCOS患者中发现了血内醇 (IS,IAA,IND) 的升高,与葡萄糖代谢受损和胰岛素抵抗相关.

科学领域:

内分泌学在内分泌学.
代谢综合征是代谢综合征的一种.
微生物组研究微生物组研究

背景情况:

多囊卵巢综合征 (PCOS) 是生育年龄女性常见的内分泌疾病.
肠道微生物群的变化越来越被认为是PCOS病变的潜在贡献者.
来自微生物群的英多尔与代谢调节有关,特别是血糖控制.

研究的目的:

为了研究PCOS妇女血内醇水平的变化.
在PCOS中探索血英多尔度和葡萄糖代谢标志物之间的相关性.
评估血内醇对PCOS的诊断潜力.

主要方法:

用光检测的高性能液体染色学 (HPLC) 测量了五种印的血度 (硫酸印,印-3-酸,印-3-,印,3-甲基印).
65名患有PCOS的女性和28名年龄相匹配的对照被招募.
进行了统计分析,包括相关性和后勤回归.

主要成果:

与对照组相比,PCOS患者的胰岛素硫酸 (IS),胰岛素-3-酸 (IAA) 和胰岛素 (IND) 的血水平显著更高.
升高的IS,IAA和IND水平与禁食葡萄糖,禁食胰岛素和HOMA-IR正相关.
IS和IND被确定为PCOS的风险因素,综合的英多尔指数显示出良好的诊断准确性 (AUC=0.867).

结论:

在患有PCOS的女性中,血内的形状发生变化.
这些内醇变化与PCOS中失调的葡萄糖代谢和胰岛素抵抗密切相关.
血内醇可以作为PCOS诊断的潜在生物标志物和代谢功能障碍的指标.

关键词:

类似葡萄糖的1 类似葡萄糖1 葡萄糖的新陈代谢.印度人是印度人,印度人是印度人.胰岛素耐药性胰岛素耐药性是一种多囊性卵巢综合征多囊性卵巢综合征

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