相关实验视频

Updated: Jul 13, 2025

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

高CCDC69的表达与免疫疗法反应和对乳腺癌的保护作用相关

Zhen Wang¹, Huiyang Ren², Guolian Zhu³

¹Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

|October 12, 2023

概括

在乳腺癌中,卷曲卷曲域含有蛋白69 (CCDC69) 的下调,但更高的表达预测了更好的预后和免疫疗法反应. 这项研究强调了CCDC69在瘤免疫力中的作用.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

卷状卷状域含蛋白69 (CCDC69) 对于细胞分裂至关重要,并与各种癌症有关.
目前尚不清楚CCDC69在乳腺癌免疫力和免疫治疗反应中的作用.

研究的目的:

研究CCDC69在乳腺癌中的表达,预后价值和与免疫相关的功能.
确定CCDC69与免疫细胞透之间的关联,以及其对免疫疗法反应的预测潜力.

主要方法:

使用定量实时PCR,免疫组织化学和TCGA数据库分析来评估CCDC69的表达和预后.
用基因组丰富分析,单细胞分析 (IMMUcan) 和蛋白质-蛋白质相互作用网络 (STRING,Cytoscape) 来探索CCDC69的功能.
使用TISIDB,CAMOIP和TISMO分析免疫细胞透,共同表达的免疫基因和免疫疗法反应相关性.

主要成果:

与正常组织相比,CCDC69的mRNA表达在乳腺癌组织中显著下调.
较高的CCDC69表达与改善的乳腺癌预后相关,并与瘤抑制免疫细胞 (包括T细胞和树突细胞) 的透率增加有关.
增加的CCDC69表达预测了对免疫治疗的更好的反应,并且在体外用干扰素-治疗时被上调调节.

结论:

CCDC69在乳腺癌中起着重要作用,作为潜在的瘤抑制剂.
CCDC69表达是预测乳腺癌患者免疫透和免疫治疗反应的可靠生物标志物.

关键词:

生物标志物生物标志物乳腺癌乳腺癌乳腺癌 CCDC69 疾病预防控制中心免疫系统的透.免疫治疗是一种免疫疗法.

更多相关视频

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Published on: December 16, 2022

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...