不同的胰岛素抵抗替代体与生育年龄女性不孕症之间的关联
Weiting Xia1, Yaoyao Cai2, Sisi Zhang3
1Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
BMC public health
|October 12, 2023
概括
高水平的TyG-BMI指数与美国妇女的女性不孕症有关. 这一发现强调了TyG-BMI指数作为生育年龄女性不孕症风险的潜在指标.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 肥胖和代谢综合征在不育妇女中很普遍,通常与胰岛素抵抗 (IR) 相关.
- 以前的研究还没有探讨各种IR代孕和女性不孕症之间的关联.
- 本研究通过调查一般人群中的IR替代品来弥补这一差距.
研究的目的:
- 检查不同抗胰岛素 (IR) 代孕产物与女性不孕症之间的关联.
- 确定与美国生育年龄妇女不孕症相关的潜在IR标志物.
主要方法:
- 采用2013-2018年国家健康和营养检查调查 (NHANES) 数据进行的横截面研究.
- 使用多变量回归分析来评估HOMA-IR,TyG指数和TyG-BMI指数与女性不孕症的关联.
- 进行了分层分析,以评估各子组的一致性.
主要成果:
- 在对混因素进行调整后,HOMA-IR指数和TyG指数与女性不孕症没有显著关联.
- 泰格-BMI指数显示出与女性不孕症的积极关联 (OR=1.01,P<0.0001).
- 较高的TyG-BMI指数组 (T3) 与最低的组 (T1) (OR=3.02) 相比,不孕不育的几率显著增加.
结论:
- 提升的TyG-BMI指数水平与美国生育年龄妇女的女性不孕症有关.
- TyG-BMI指数可以作为评估不孕症风险的有价值指标.
- 进一步的研究可以探索TyG-BMI指数在生殖健康评估中的临床实用性.
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