随机的第三阶段试验评估激励面试和文字干预,以优化乳腺癌内分泌治疗的坚持 (联盟A191901):GETSET协议
Joannie Ivory1,2, Stephanie B Wheeler3,4, Sarah Drier3,4
1University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. joannie_ivory@med.unc.edu.
Trials
|October 12, 2023
概括
这项研究调查了短信提醒和激励面试,以改善激素受体阳性乳腺癌幸存者的内分泌治疗的坚持. 干预措施旨在提高不同人群的药物坚持和患者报告的结果.
科学领域:
- 在瘤学瘤学.
- 临床试验 临床试验
- 医疗保健服务研究 医疗服务研究
背景情况:
- 激素受体阳性乳腺癌很常见,口服内分泌疗法 (ET) 对长期结果至关重要.
- 坚持每天的ET是至关重要的,但具有挑战性,尤其对年轻人和黑人女性来说.
- 不遵守ET可以限制乳腺癌幸存者的治疗疗效.
研究的目的:
- 测试短信提醒 (TMR) 和激励面试 (MI) 对ET坚持的有效性.
- 评估TMR和/或MI对患者报告结果 (PRO) 和资源使用的影响.
- 改善HR+乳腺癌幸存者的ET坚持,特别是在代表性不足的群体中.
主要方法:
- 联盟试验A191901是一个四臂随机临床试验 (TMR,MI,TMR+MI,增强常规护理).
- 招募了1180名参与者,对年轻女性和黑人女性 (30%分别) 进行过量抽样.
- 主要终点:12个月以Pillsy cap测量ET坚持;通过联盟ePRO应用程序评估PROs.
主要成果:
- 初级分析将在12个月内对四个研究部门的ET坚持率进行比较.
- 还将分析干预对患者报告结果和资源利用的影响.
- 该研究旨在确定有效的策略,以改善乳腺癌护理中的药物坚持.
结论:
- 这项研究将确定改善对口服乳腺癌治疗方法的遵守的策略.
- 研究结果可能支持在临床研究中针对不同患者群体进行可扩展,具有成本效益的干预措施.
- 这项研究探讨了远程和有吸引力的方法,以支持乳腺癌幸存者的ET坚持.
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