纯能信号及其在干细胞分化中的作用
Sumera Zaib1, Areeba1, Imtiaz Khan2
1Department of Basic and Applied Chemistry, Faculty of Science and Technology, University of Central Punjab, Lahore, 54590, Pakistan.
Mini reviews in medicinal chemistry
|October 13, 2023
概括
purinergic 信号传递,涉及 purin 和 pyrimidin 的细胞受体,影响细胞活动,并在干细胞治疗中显示出有前途的组织修复和疾病治疗.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 纯能信号传递涉及与细胞表面受体 (P1和P2家族) 相互作用的细胞外 purin/pyrimidine.
- P1受体与腺结合;P2受体与 purin/pyrimidine结合,包括P2X离子通道和P2Y G-蛋白结合受体.
- 纯能信号的失调与各种疾病有关,并影响神经元和非神经元细胞活动.
研究的目的:
- 探索纯能信号传递的分子机制.
- 研究纯能信号在干细胞移植和治疗应用中的作用.
- 了解纯能受体亚型如何影响受损组织和疾病治疗.
主要方法:
- 关于纯能信号通路和受体亚型 (P2X1-7,P2Y1/2/4/6/11/12/13/14) 的文献综述.
- 分析纯能信号对细胞增殖和分化等过程的影响.
- 检查免疫系统调解者在干细胞治疗的纯能信号传递中的作用.
主要成果:
- 纯能信号机制为治疗人类疾病提供了洞察力.
- 纯能信号显示出对干细胞移植的积极影响.
- 免疫系统激活自身隐性/隐性机制对于成功的干细胞治疗至关重要.
- 个别的纯能受体亚型对受损组织产生有益影响,促进增殖和分化.
结论:
- 了解纯能信号是开发各种疾病新型治疗策略的关键.
- 纯能信号传递在增强干细胞治疗结果方面发挥着重要作用.
- 准纯能受体可能为再生医学和组织修复提供了一条途径.
更多相关视频
11:40Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
Published on: October 20, 2014
8.5K
08:06Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions
Published on: July 2, 2020
4.6K
相关概念视频
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
01:26Stem Cell Niche
5.1K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.1K
01:01Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
01:21Lineage Commitment
3.0K
Commitment is the process whereby stem cells:
3.0K
01:19Multipotency of Hematopoietic Stem Cells
3.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.1K
01:14Maintenance of the ES Cell State
2.2K
The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
2.2K