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旋转手套肌肉纤维化可以使用超短回声时间磁化转移MRI与脂肪抑制进行评估
Eric Y Chang1,2, Arya Suprana2,3, Qingbo Tang2,4
1Radiology Service, VA San Diego Healthcare System, San Diego, California, USA.
NMR in biomedicine
|October 13, 2023
概括
具有脂肪抑制 (FS) 的定量超短回声时间磁化转移 (UTE-MT) 可以在受伤后检测旋转手套肌肉中的纤维化. 这种技术对评估肌肉退化独立于脂肪透有希望.
科学领域:
- 生物医学工程 生物医学工程
- 放射学 放射学是一门学科.
- 整形外科 整形外科 整形外科
背景情况:
- 旋转的撕裂导致肌肉退化,包括脂肪透和纤维化.
- 肌肉纤维化的非侵入性评估具有挑战性,限制了对损伤进展的理解.
研究的目的:
- 为了评估定量超短回声时间T1 (UTE-T1) 和UTE磁化转移 (UTE-MT) 映射与或没有脂肪抑制 (FS).
- 使用这些成像技术来区分受伤者和控制旋转手套肌肉,并检测纤维化.
主要方法:
- 使用了一种慢性巨大的旋转手套撕裂的老鼠模型.
- 在3T扫描仪上进行了UTE-T1和UTE-MT映射 (含FS和不含FS).
- 组织学测量了连接组织分数 (CTF);MRI测量了T1和宏分子分数 (MMF).
主要成果:
- 在受伤和控制旋转手套肌肉之间发现了CTF的显著差异.
- 使用UTE-MT与FS的宏分子分数 (MMF) 在受伤者和对照者之间显示出显著的差异.
- 只有使用UTE-MT的MMF与FS与CTF有显著的相关性,表明纤维化检测.
结论:
- 纤维化是旋转手腕肌肉退化的组成部分.
- 与FS一起的UTE-MT是一种有前途的技术,用于评估肌肉退化的纤维化成分,独立于脂肪透.
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