在老年人中不健康的白质连接性,认知和种族化
Sarah K Royse1,2, Beth E Snitz3, James B Hengenius1
1Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|October 13, 2023
概括
不健康的白质连接性 (UWMC) 与阿尔茨海默病 (AD) 的认知衰退有关. 较高的UWMC负担,而不是不同的关联,可能解释了与非西班牙裔白人相比,黑人美国人的AD负担更大.
科学领域:
- 神经科学是一个神经科学.
- 神经病理学神经病理学
- 老年学是指老年学的学科.
背景情况:
- 白质超强度 (WMH) 与种族化群体之间的阿尔茨海默病 (AD) 差异有关.
- 调查白质完整性的新指标对于理解认知衰老至关重要.
研究的目的:
- 检查白质超强度 (WMH) 与认知之间的关系中的种族化群体差异.
- 引入和利用不健康的白质连接 (UWMC) 作为一种新的白质完整性测量方法.
主要方法:
- UWMC被计算为穿过WMH的大脑区域对之间的白质纤维的比例.
- 回归模型评估了AD病理受影响区域与认知的UWMC的关联.
- 分析按种族化群体 (黑人美国人与非西班牙裔白人) 进行了分层分析,并使用了相互作用术语.
主要成果:
- 美国黑人参与者比非西班牙裔白人参与者表现出更高的UWMC和较差的认知能力.
- 在受β-粉样蛋白和tau病理影响的区域,UWMC与认知有负相关性.
- 种族化组没有显著改变UWMC-认知关系.
结论:
- 不同的UWMC负担,而不是与认知的不同关联,可能会导致临床AD差异.
- 确定UWMC的风险因素,特别是社会和环境风险因素,对于有针对性的干预措施至关重要.
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