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血流感染中的グラム阴性病原体中药物耐药性的增加:在内蒙古乌兰霍特的一项多中心研究 (2017-2021年)

Yinxia Feng¹, Zhijun Wang¹, Zelin Hao²

¹Department of Laboratory Medicine, Xing'an League People's Hospital, Xing'an League, Ulanhot, Inner Mongolia, China (mainland).

Medical science monitor : international medical journal of experimental and clinical research

|October 13, 2023

概括

格拉姆阴性细菌,特别是大肠杆菌和肺炎菌,是乌兰霍特血流感染的主要原因. 像Acinetobacter baumannii这样的菌株的高耐药性需要紧急监测和战略性抗生素使用.

科学领域:

医学微生物学医学微生物学
传染性疾病传染性疾病
抗微生物耐药性抗微生物耐药性

背景情况:

血流感染 (BSI) 由于其潜在的致命性和系统性影响,对健康构成重大威胁.
了解病原体分布和抗菌素敏感性对于有效的BSI管理至关重要.

研究的目的:

为了确定引起血液感染的病原体的药物敏感性概况.
分析这些病原体在内蒙古乌兰霍特的分布.

主要方法:

分析了2017年至2021年期间采集的2498个血培养阳性样本.
病原体的识别和药物敏感性测试使用仪器方法,纸张扩散和度测试 (E-测试).
使用WHONET 5.6软件进行微生物分布和耐药性模式的数据分析.

主要成果:

格拉姆阴性细菌 (62.45%) 占主导地位,其中大肠杆菌 (35.15%) 和肺炎菌 (15.73%) 是最常见的病原体.
在对青素G (80.87%-100.00%) 和红素 (91.16%-97.28%) 的甲素耐药菌株中观察到高耐药率.
宝曼尼菌 (Acinetobacter baumannii) 的药物耐药性高于Pseudomonas aeruginosa的药物耐药性 (耐药性为30.00%).

结论:

格拉姆阴性细菌,特别是大肠杆菌和肺炎菌,是乌兰霍特地区BSI的主要原因.
增加抗菌素耐药性,特别是在Acinetobacter baumannii中,需要加强监测和明智的抗生素管理.
保持抗生素疗效对于未来的治疗成功至关重要.

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