2型糖尿病和肥胖对心肺功能的明显影响
Lorenzo Nesti1,2, Nicola Riccardo Pugliese2, Lorenza Santoni1
1Metabolism, Nutrition, and Atherosclerosis Laboratory, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Diabetes, obesity & metabolism
|October 13, 2023
概括
2型糖尿病 (T2D) 在没有心脏或肺部疾病的个体中独立降低运动能力 (VO2峰值). 这种效应是身体质量指数 (BMI) 的附加效应,突出T2D作为努力不耐受的一个重要因素.
科学领域:
- 心脏病学和运动生理学
- 代谢性疾病研究研究
背景情况:
- 在超重/肥胖和2型糖尿病 (T2D) 患者中,即使没有被诊断出心脏或呼吸系统疾病,也很常见的劳动不耐受.
- 了解T2D和身体质量指数 (BMI) 对心肺功能减弱的独立贡献,对于有效管理至关重要.
研究的目的:
- 量化T2D和BMI对心肺能力 (VO2峰值) 的独立影响.
- 调查导致这些患者群体运动耐受性降低的潜在病理生理学.
主要方法:
- 对正在接受临床治疗的患者进行了病例控制和回归分析,包括螺旋计和心声图-心肺运动测试.
- 排除标准是针对现有心肺疾病的个人.
- 多变量模型评估了T2D和肥胖对高峰氧气吸收 (VO2峰值) 的影响,为无脂肪质量 (FFM) 规范化,控制混因素.
主要成果:
- 患有T2D的患者 (n=109) 的BMI显著高于对照组 (n=97),但可比较的无脂肪质量.
- 与对照组相比,T2D患者的VO2峰值较低 (18.5比21.7毫升/分钟/公斤,p=0.0006).
- 在T2D患者中发现了亚临床心血管功能障碍,包括左心室重塑和自主功能障碍. T2D仍然是VO2峰值的独立负决定因素 (p=0.0089),而BMI的影响在很大程度上是由其他因素解释的.
结论:
- 2型糖尿病是氧气吸收峰值 (VO2峰值) 的独立负决定因素.
- 二型糖尿病对运动能力的有害影响是其他病理生理因素的附加因素,包括BMI升高.
- 这些发现强调了解决T2D在管理劳力不耐症方面的重要性.
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