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Updated: Jul 13, 2025

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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溶解融合蛋白凝结物以逆转异常基因表达

Hazheen K Shirnekhi1, Bappaditya Chandra1, Richard W Kriwacki1,2

  • 1Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Cancer research
|October 13, 2023
PubMed
概括

癌症融合蛋白质形成异常的凝聚物,驱动疾病. 一个新的屏幕确定了像LY2835219这样的化合物,通过促进 lysosome 形成来溶解这些致癌凝聚物,从而提供了一个治疗策略.

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