低ALT水平的患者面临严重COVID-19的风险增加
Dor Genzel1, Lior H Katz1,2, Rifaat Safadi1,3
1Hadassah Medical School, Hebrew University of Jerusalem, Jerusalem, Israel.
Frontiers in medicine
|October 13, 2023
概括
感染前低氨酸转胺酶 (ALT) 水平与更高的COVID-19严重结果风险有关,包括死亡率和长时间住院治疗. 这一发现凸显了ALT作为弱势群体的潜在指标.
科学领域:
- 生物化学 生物化学
- 流行病学 流行病学
- 传染性疾病 传染性疾病
背景情况:
- 脆弱性是严重的COVID-19的一个重要风险因素.
- 诊断虚弱可能具有挑战性,导致许多患者的诊断不足.
- 在肌肉和肝脏中发现的低氨酸转胺酶 (ALT) 水平与脆弱性和肉症有关.
研究的目的:
- 调查感染前阿氨酸转胺酶 (ALT) 水平与严重COVID-19的风险之间的关联.
- 为了确定低ALT是否是COVID-19患者不良结果的预测因素.
主要方法:
- 来自以色列国家卫生数据库的超过58,000名SARS-CoV-2阳性患者的回顾性分析 (2020年3月 - 2021年12月).
- 收集的临床和实验室数据,包括感染前一年的ALT水平.
- 定义严重的COVID-19为死亡,ICU入院或住院时间≥10天. 低ALT (≤10 IU/l) 患者与正常ALT (11-40 IU/l) 患者进行比较,不包括特定的患者群体.
主要成果:
- 低ALT患者年轻,不太可能是男性,与正常ALT患者相比,BMI较低.
- 低ALT组的死亡率 (2.36%vs0.57%) 和住院时间长 (2.63%vs0.98%) 显著增加.
- 多变量分析显示,低ALT是增加COVID-19死亡率 (OR 1.88) 和长时间住院治疗 (OR 1.78) 的独立风险因素.
结论:
- 感染前低ALT水平是COVID-19患者患病率和死亡率增加的重要预测因素.
- 这表明ALT可以作为生物标志物来识别患重症COVID-19风险较高的个体.
- 建议进行进一步的研究,以探索低ALT患者的治疗策略.
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