调节T细胞作为自身免疫和癌症中的细胞疗法
Hamed Hosseinalizadeh1, Fatemeh Rabiee2, Negar Eghbalifard3
1Department of Medical Biotechnology, Faculty of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran.
Frontiers in medicine
|October 13, 2023
概括
调节性T细胞 (Tregs) 对于免疫平衡至关重要,但可以驱动自身免疫或癌症. 重编程Tregs通过调节它们的免疫抑制功能,为自身免疫疾病提供了向治疗,并改善了癌症免疫疗法.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 这是一种自身免疫力.
背景情况:
- 调节性T细胞 (Tregs) 维持免疫的平衡.
- 失调的Tregs与自身免疫性疾病和癌症有关.
- 由于Tregs具有免疫抑制性,因此对癌症免疫疗法构成挑战.
研究的目的:
- 为了阐明Treg功能在瘤和自身免疫.
- 探索用于重编程Treg功能的治疗策略.
- 讨论针对自身免疫和癌症的基于Treg的疗法.
主要方法:
- 对Treg功能在自身免疫和癌症中的审查.
- 针对Treg激活,表面受体和代谢的治疗策略的分析.
- 对化学抗原受体 (CAR) -Treg和T细胞受体 (TCR) -Treg疗法的检查.
主要成果:
- 对Treg的稳定性是控制自身免疫性炎症的关键.
- 在癌症中过度激活的Tregs阻碍了免疫疗法的有效性.
- 针对Tregs需要选择性方法来避免系统性毒性.
结论:
- 重编程Tregs为治疗自身免疫性疾病和增强癌症免疫治疗提供了一个有希望的策略.
- 有针对性的Treg调节,包括CAR-Treg和TCR-Treg疗法,显示出潜力.
- 需要进一步的研究来克服针对新型疗法的选择性Treg重编程的挑战.
相关概念视频
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Tumor Immunotherapy
539
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
539
Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Inflammatory Response
2.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.1K
T Cell Activation and Clonal Selection
774
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
774
Cell-mediated Immune Responses
68.6K
Overview
68.6K


