结合多种omics技术进行个性化治疗或治疗选择
Chiara Massa1, Barbara Seliger1,2,3
1Institute for Translational Immunology, Brandenburg Medical School Theodor Fontane, Brandenburg an der Havel, Germany.
Frontiers in immunology
|October 13, 2023
概括
个性化癌症治疗至关重要,因为"一刀切"的疗法失败了. 结合预测生物标志物与个体瘤"omics"分析和ex vivo测试,优化了患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
背景情况:
- 向疗法和免疫疗法改善了癌症治疗,但对于许多患者来说,长期反应有限.
- 瘤突变负担,瘤微环境,免疫系统,微生物群和免疫逃生机制的个体患者变化需要个性化治疗策略.
研究的目的:
- 突出个性化癌症治疗策略的需要.
- 提出一种综合方法,以确定针对个体癌症患者的最佳治疗方法.
主要方法:
- 利用从大型患者队列中确定的预测生物标志物.
- 采用基于"omics"的分析来对个体瘤进行表征.
- 进行瘤对各种疗法的ex vivo敏感性测试.
主要成果:
- 当前广泛的治疗方法产生有限的长期反应.
- 在影响治疗疗效的因素中存在显著的患者间异质性.
- 个性化方法对于有效的癌症管理至关重要.
结论:
- 在瘤学中,个性化的治疗模式是必不可少的.
- 结合预测生物标志物和全面的个体瘤概况 (omics和ex vivo测试) 是优化患者反应和实现长期结果的关键.
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