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中性粒细胞外细胞陷和长期的COVID

Areez Shafqat¹, Mohamed H Omer², Ibrahem Albalkhi¹

¹College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

Frontiers in immunology

|October 13, 2023

概括

中性细胞外细胞陷 (NETs) 可能通过引起持续的炎症来驱动长期的COVID症状. 对NET的进一步研究可能会导致对这种新出现的健康危机的新疗法.

科学领域:

免疫学免疫学免疫学
病理生理学病理生理学
在COVID-19研究研究中.

背景情况:

后急性COVID-19后遗症,或长期COVID,在幸存者中呈现出各种系统性症状.
慢性炎症是公认的,但中性粒细胞的作用,关键的免疫反应者,是研究不足的.
中性细胞外细胞陷 (NETs) 与持续性炎症有关.

研究的目的:

审查NETs在长期COVID病理生理学的新兴作用.
突出早期证据,将NET与特定的长期COVID连续症联系起来.
确定未来对NET和长期COVID的研究的关键问题.

主要方法:

关于中性粒细胞,NET和长期COVID的当前研究的文献综述.
综合早期证据,将NET持续性与长期COVID症状联系起来.
识别知识缺口和未来的研究方向.

主要成果:

早期证据表明,在长期的COVID中,持续的NET和肺纤维化,心血管问题和神经功能障碍之间存在联系.
由于SARS-CoV-2引起的持续中性粒细胞激活和NET形成的精确机制需要进一步阐明.
建议自抗体和细胞衰老在长期COVID中NET形成中的潜在作用.

结论:

网络代表了长期COVID管理的潜在治疗目标.
进一步研究NET的形成,持久性和器官特异性影响至关重要.
回答关键研究问题可能有助于制定针对性临床策略,以缓解长期的COVID.

关键词:

在 COVID-19 疫情中,自体免疫性是一种自身免疫性.纤维化纤维化这是一种炎症炎症炎症炎症.长时间的Covid.中性粒细胞外细胞陷中性粒细胞中性粒细胞.血栓形成的原因是血栓形成.

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