儿童注意力缺陷/多动障碍的默认模式网络连接和社会功能障碍
Ahmed Ameen Fateh1, Wenxian Huang2, Muhammad Hassan1
1Department of Radiology, Shenzhen Children's Hospital, Shenzhen 518038, China.
International journal of clinical and health psychology : IJCHP
|October 13, 2023
概括
在注意力缺陷/多动障碍 (ADHD) 中的社会困难与改变的默认模式网络 (DMN) 连接有关. 在特定的大脑区域减少DMN连接可能是ADHD儿童的社会功能障碍的基础.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 儿童精神病学 儿童精神病学
背景情况:
- 注意缺陷/多动症 (ADHD) 严重损害了社会功能.
- 在ADHD中,社会功能障碍的神经生物学基础尚未完全理解.
- 默认模式网络 (DMN) 中的连接性变化是ADHD中社会缺陷的潜在贡献者.
研究的目的:
- 研究DMN中的动态功能连接 (dFC) 变化与ADHD儿童的社会功能障碍之间的关联.
- 探索特定的DMN子系统,包括中间叶 (MTL) 和中线核心,与ADHD相关的社会障碍相关.
主要方法:
- 使用了休息状态功能磁共振成像 (fMRI).
- 该研究包括40名男性ADHD患者 (7-10岁) 和45名健康对照 (HC).
- 分析集中在DMN子系统中的dFC和与临床症状的相关性.
主要成果:
- 与HC相比,ADHD患者的DMN连接性降低,特别是在MTL子系统和中线核心内,与HC相比.
- 在近海马皮层 (PHC) 和左上额外回环之间,以及在腹中前额外皮层 (vMPFC) 和右中额外回环之间观察到dFC的具体下降.
- 在ADHD患者的后侧环状皮质 (PCC),前侧中间前额叶皮质 (aMPFC) 和直角环之间,还注意到dFC的进一步减少.
结论:
- 改变的DMN连接,特别是在MTL和中线核心,与ADHD的社会功能障碍有关.
- 这些发现提供了对ADHD中社会障碍的神经生物学和病理生理学的见解.
- 该研究强调了DMN功能连接在理解ADHD相关的社会缺陷中的作用.
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