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解锁非编码RNA在前列腺癌进展中的作用:探索与Wnt信号通路的相互作用

Tong Bu¹, Le Li¹, Jiyu Tian¹

¹Department of Gastroenterology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.

Frontiers in pharmacology

|October 13, 2023

概括

非编码RNAs (ncRNAs) 调节前列腺癌 (PCa) 中的Wnt信号通路,影响细胞行为和治疗反应. 了解这些ncRNA为PCa诊断和治疗提供了新的策略.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

前列腺癌 (PCa) 由于其多样化的临床行为,提出了诊断和治疗方面的挑战.
包括古典和非古典路线在内的Wnt信号通路对于正常发育至关重要,并与PCa有关.
非编码RNAs (ncRNAs) 是细胞过程中的关键调节者,并参与PCa的发展和治疗.

研究的目的:

概述了ncRNAs在前列腺癌进展过程中的Wnt信号通路中的调节作用.
审查微RNA,长非编码RNA和圆形RNA在PCa中的Wnt通路调节中的参与.
探索ncRNAs,Wnt信号传递和新型治疗策略的临床特征之间的相关性.

主要方法:

文献综述侧重于ncRNAs和前列腺癌中的Wnt信号传递.
对研究ncRNAs对Wnt路径组件的影响的分析.
对ncRNA表达模式及其与PCa特征的关联研究的综合.

主要成果:

异常的ncRNA表达和Wnt通路失调驱动PCa细胞的增殖,细胞亡,入侵,迁移和血管生成.
特定的ncRNAs,包括miRNAs,lncRNAs和circRNAs,是PCa中Wnt信号的关键调节者.
这些ncRNAs影响PCa细胞表型,并显示出作为诊断和预后生物标志物的潜力.

结论:

ncRNAs在调节前列腺癌中Wnt信号传递方面发挥着重要作用.
对ncRNA-Wnt相互作用的失调有助于PCa的发病.
准参与Wnt信号传递的ncRNA为PCa治疗和生物标志物开发提供了有前途的途径.

关键词:

没有信号通路.环RNA 环RNA 是一个环RNA.在ncRNA中,我们可以这是一个小RNARNA.没有编码的RNA.前列腺癌是前列腺癌.

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