垂直传播并不总是导致良性病原体与宿主关联
George Shillcock1, Francisco Úbeda2, Geoff Wild1
1Department of Mathematics, Western University, London, Canada.
Evolution letters
|October 13, 2023
概括
病原体的垂直传播并不总是意味着疾病的严重程度会降低. 这项研究表明,宿主进化可以导致更多的毒性病原体,挑战以前关于宿主-病原体动态的假设.
科学领域:
- 进化生物学是进化的生物学.
- 病原体动态 病原体动态
- 疾病生态学 疾病生态学
背景情况:
- 病原体可以在宿主之间水平传播或从父母向后代垂直传播.
- 垂直传播通常被认为可以减少病原体的毒性.
- 以前的模型往往忽略了宿主的进化反应.
研究的目的:
- 研究病原体宿主系统中垂直传播的进化后果.
- 确定垂直传播是否始终导致不那么致命的病原体.
- 确定垂直传播可能增加病原体毒性的条件.
主要方法:
- 利用游戏理论模型模拟宿主和病原体之间的共同进化.
- 将宿主进化反应纳入传输动态中.
- 分析了不同传播方式和宿主人口增长率的场景.
主要成果:
- 垂直传播并不总是导致不那么致命的病原体.
- 现有场景中,垂直传播会导致病原体毒性增加.
- 从水平感染减少宿主损害,高成本的感染清除,和快速的宿主人口增长有利于较少的毒性结果.
结论:
- 垂直传播和病原体毒性之间的关系是复杂的,并且取决于背景.
- 宿主进化反应对于塑造毒性进化的过程至关重要.
- 这些发现挑战了长期以来的假设,即垂直传播总是减弱病原体.
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