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Updated: Jul 13, 2025

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

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在肺腺癌初级样本中,MET 突变14 突变因子以异位基因特异的方式过度表达

Megan Durham1, Swetha Vadde1, Angela N Brooks2

  • 1Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California, United States.

microPublication biology
|October 13, 2023
PubMed
概括

跳过MET外显子14 (METΔ14) 驱动肺腺癌 (LUAD). 这种癌基因以异位基因特异的方式过度表达,这表明其剂量对癌症发展至关重要.

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相关概念视频

Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon...
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