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轻度创伤性脑损伤中被破坏的静止状态功能连接和网络拓:一项动脉旋转标记研究

Fengfang Li¹, Liyan Lu¹, Hui Li²

¹Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.

Brain communications

|October 13, 2023

概括

轻度创伤性脑损伤 (mTBI) 破坏大脑血流网络,影响大脑连接和认知功能. 这些血液流动网络的变化可以作为mTBI的早期诊断标记.

科学领域:

神经科学是一个神经科学.
放射学放射学是一门学科.
医疗成像医学成像

背景情况:

轻度创伤性脑损伤 (mTBI) 与认知障碍和改变的大脑结构/连接性有关.
关于脑血流 (CBF) 网络功能连接和急性mTBI的拓学的研究是有限的.

研究的目的:

在急性mTBI患者中调查CBF,功能连接和CBF网络的拓组织.
探索CBF网络变化与mTBI中的认知功能之间的相关性.

主要方法:

在48名mTBI患者和46名健康对照中进行了静止状态动脉旋转标记输液MRI和神经心理评估.
分析CBF网络的功能连接和拓组织.
对CBF网络特征和认知分数之间的相关性分析.

主要成果:

mTBI患者在特定的大脑区域 (例如,右侧胰岛,旋) 呈现出改变的CBF.
在传感器运动,默认模式,环眼和头网络中观察到异常的CBF网络连接.
mTBI 破坏了全球大脑拓,包括降低了全球效率和改变了节点特性,尾和感觉运动网络之间的连接性减少.

结论:

急性mTBI的特征是脑血流的异常功能连接和网络拓.
CBF网络的变化显示出作为mTBI诊断和评估的早期生物标志物的潜力.

关键词:

动脉旋转标签的标签功能连接性的功能连接性图形理论中的图形理论.轻微的创伤性脑损伤.模块模块模块模块模块模块

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