患有非ST段升高心肌梗塞的患者的身体脂肪百分比和心脏病发作大小
Aylin Sungur1, Mustafa Azmi Sungur2, Baris Simsek2
1Department of Cardiology, Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkiye.
Northern clinics of Istanbul
|October 13, 2023
概括
较高的体脂百分比 (BFP) 与非ST段升高心肌梗塞 (NSTEMI) 患者的心脏病发作规模较小有关. 这一发现支持肥胖悖论,表明患有心脏病的肥胖个体的结果更好.
科学领域:
- 心脏病学 心脏病学
- 代谢障碍 代谢障碍 代谢障碍
- 临床研究 临床研究
背景情况:
- 肥胖是一个全球性的健康问题,与冠状动脉疾病 (CAD) 风险增加有关.
- "肥胖悖论"表明,对于已确诊的CAD的肥胖患者来说,预后可能更好.
- 现有的研究经常使用体重指数 (BMI) 来定义肥胖,但其他指标可能会提供更多的洞察力.
研究的目的:
- 为了研究肥胖之间的关系,通过身体脂肪百分比 (BFP) 和相对脂肪质量 (RFM) 来评估,以及非ST段升高心肌梗塞 (NSTEMI) 的患者的心脏病发作大小 (IS).
- 将BFP和RFM与BMI的预测值进行比较,以确定NSTEMI患者的IS.
主要方法:
- 对748名在2017年1月至2022年1月期间接受冠状动脉血管造影的NSTEMI患者的回顾性分析.
- 排除缺乏BMI,BFP,RFM计算或连续CK-MB测量的人类学数据的患者.
- 从人类测量数据计算BMI,BFP和RFM;线性回归分析以确定IS预测因素.
主要成果:
- 肥胖患者 (BMI ≥30 kg/m2) 更有可能是女性,高血压和糖尿病患者,吸烟频率较低.
- 在肥胖和非肥胖组之间,峰值肌酸激酶-MB (CK-MB) 水平在肥胖和非肥胖组之间是相似的.
- 多变量回归确定了BFP (β=-4.8,p=0.03) 作为较小的IS的独立预测因子,除了糖尿病,缩血压,白细胞计数和血红蛋白之外.
结论:
- 在NSTEMI患者中,较高的BFP与较小的心脏病发作大小有关.
- 这些发现提供了支持NSTEMI背景下肥胖悖论的证据.
- 需要进一步的随机对照研究来证实这些观察.
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