血病对呼吸功能的限制性影响:一个中心的经验
Gizem Zengin Ersoy1,2, Ercan Nain3, Mehtap Ertekin2,4
1Department of Pediatric Hematology Oncology, Pediatric Bone Marrow Transplantation Unit, Altinbas University, Medical Park Bahcelievler Hospital, Istanbul, Turkiye.
Northern clinics of Istanbul
|October 13, 2023
概括
大型沙拉西米亚 (TM) 患者的呼吸功能经常受到影响,表现为限制性模式. 年龄和身高是影响肺功能的关键风险因素,而费里水平显示较小的影响.
科学领域:
- 肺部医学 肺部医学
- 血液学 血液学 血液学
- 儿科 儿科 儿科
背景情况:
- 长期输血计划中的thalassemia major (TM) 患者经常面临并发症.
- 呼吸功能受损是TM的一个问题,可能与化状态有关.
研究的目的:
- 在接受慢性输血的TM患者中评估肺功能.
- 为了将肺功能测试 (PFT) 结果与患者年龄,费里丁水平和输血前血红蛋白相关联.
主要方法:
- 对97名没有其他呼吸道疾病的TM患者进行了PFT (FVC,FEV1,PEF,MEF25-75).
- 记录患者的人口统计,输血前的血红蛋白和血清费里水平.
- 使用IBM SPSS V25.25进行数据分析.
主要成果:
- 78.1%的患者表现出异常的PFT,主要具有限制性模式.
- 在60%和27.6%的患者中,分别观察到低强迫生命能力 (FVC) 和1秒强迫呼吸量 (FEV1).
- 年龄和身高显著影响FEV1和MEF25-75;费里水平与MEF25-75.微弱相关.
结论:
- 年龄和身高是TM患者肺功能减弱 (FEV1,MEF25-75,PEF) 的主要危险因素.
- 血清费里水平显示影响有限,主要影响MEF25-75.
- 肌痛转移患者表现出呼吸功能障碍,其特点是限制性模式.
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