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在前列腺癌中,nectin-4的表达

Melike Ordu¹, Mustafa Karaaslan², Mehmet Emin Sirin³

¹Department of Medical Pathology, Aksaray University Faculty of Medicine, Aksaray, Turkiye.

Northern clinics of Istanbul

|October 13, 2023

概括

尼克-4在前列腺癌中没有表达,但在良性前列腺和非典型的小瘤扩散 (ASAP) 中发现. 需要进一步的研究来澄清nectin-4的含量.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
在瘤学瘤学.
分子生物学分子生物学

背景情况:

涅-4是一种跨膜蛋白,在胎盘和气管中表达.
在各种癌症类型中观察到Nectin-4表达.
在前列腺癌中,nectin-4的作用尚不清楚.

研究的目的:

首次研究人类前列腺癌组织中的nectin-4表达.
为了比较前列腺癌,非典型的小细胞扩散 (ASAP) 和良性前列腺腺体中的nectin-4表达.

主要方法:

82个前列腺病理样本的回顾性分析.
尼克丁-4和α-甲基-CoA赛马酶 (AMACR) 表达的免疫组织化学分析.
组织化学评分系统用于量化nectin-4染色强度和程度.

主要成果:

在任何前列腺癌组织中都没有检测到nectin-4 (Gleason分数<7,7,或≥8).
尼克-4在良性前列腺组织中得到表达.
在所有非典型的小菌增殖 (ASAP) 样本 (100%) 中发现了nectin-4.
在前列腺癌组织中AMACR呈阳性,在ASAP样本中呈阴性.

结论:

在前列腺癌中,nectin-4没有表达.
在ASAP和良性前列腺组织中存在nectin-4表达.
用更大的样本大小进行前性研究,包括急性前列腺切除样本,有必要阐明nectin-4和前列腺癌之间的关系.

关键词:

非典型的小虫扩散.表达方式表达方式表达方式表达尼克-4的使用方法前列腺癌是前列腺癌.

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