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术前动脉乳酸和A型大动脉剖析手术后的结果:ERTAAD多中心研究
Fausto Biancari1,2, Francesco Nappi3, Giuseppe Gatti4
1Heart and Lung Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Heliyon
|October 13, 2023
概括
手术前的动脉乳酸水平是急性A型大动脉解剖手术 (TAAD) 患者死亡率的重要预测因素. 较高的乳酸盐度与增加的住院死亡风险相关.
科学领域:
- 心血管外科心血管外科
- 关键护理医学 关键护理医学
- 生物标志物在医学中的作用
背景情况:
- 急性A型大动脉解剖 (TAAD) 存在高死亡和发病风险.
- 有效的预后标志物对于管理TAAD患者至关重要.
研究的目的:
- 为了评估手术前动脉乳酸盐度的预后意义.
- 为了确定乳酸盐水平对TAAD手术后的结果的影响.
主要方法:
- 来自ERTAAD注册表的数据分析,包括2798名接受TAAD手术的患者.
- 术前动脉乳酸盐度作为住院死亡率预测指标的统计评估.
- 用六项先前研究进行综合评估.
主要成果:
- 手术前的动脉乳酸是住院死亡率的独立预测因子 (OR 1.181).
- 乳糖切割值为1.8 mmol/L,有差异化的死亡风险 (12.0%与26.6%相比).
- 乳糖五分位数较高时,死亡率增加,在最高五分位数中达到33.6%.
结论:
- 超乳糖血症在急性TAAD手术患者中显著增加死亡风险.
- 术前的动脉乳酸应该被纳入这些关键患者的临床评估.
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