铁死涉及到糖尿病外围神经病变中的施万细胞死亡
Kai-Yan Wu1, Fei Deng1, Xin-Yu Mao1
1Department of Cell Biology, School of Medicine of Yangzhou University, Yangzhou, Jiangsu, 225009, China.
Open medicine (Warsaw, Poland)
|October 13, 2023
概括
高葡萄糖诱导ferroptosis,一个细胞死亡过程,在施万细胞中,导致糖尿病外围神经病变. 抑制铁致死提供了一个潜在的新治疗策略DPN.
科学领域:
- 生物医学科学 生物医学科学
- 细胞生物学 细胞生物学
- 神经学 神经学
背景情况:
- 由高葡萄糖 (HG) 导致的 Schwann 细胞 (SC) 死亡有助于糖尿病外围神经病变 (DPN).
- 铁,一种依赖于铁的细胞死亡途径,是HG诱导的SC死亡的潜在机制.
研究的目的:
- 为了研究铁死是否会在DPN中调解HG诱导的SC死亡.
- 探索潜在的分子机制.
主要方法:
- 在DPN患者中检测血清铁亡标志物的ELISA.
- 细胞计数套件-8,西斑,实时PCR和Ki-67染色以评估SCs.
- 使用埃拉斯和铁死抑制剂Fer-1的治疗.
主要成果:
- 在DPN患者中,血清GPX4和谷氨的含量降低,马隆迪的含量增加.
- HG和埃拉斯诱导的SC铁,降低细胞活性和GPX4/SLC7A11表达.
- 铁-1 逆转了 HG 诱导的铁亡.
- HG抑制了NRF2信号通路,促进了SC铁.
结论:
- 铁死与DPN中HG诱导的SC死亡有关.
- 针对SCs中的铁亡是一种针对DPN的新治疗方法.
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