便calprotectin和有机胃肠道疾病:一个系统的审查
Abdulaziz S Asiri1, Saad S Algarni2, Anood Q Althubaiti1
1Internal Medicine, King Faisal Medical Complex, Taif, SAU.
便calprotectin (FCP) 有效地识别患者的有机胃肠道疾病 (OGID). 这种非侵入性检查有助于区分严重疾病和功能障碍,减少不必要的结肠镜检查.
科学领域:
- 胃肠病学 胃肠病学
- 诊断的准确性 诊断的准确性
- 生物标志物研究 生物标志物研究
背景情况:
- 胃肠道症状往往需要侵入性手术,如结肠镜检查.
- 区分有机胃肠道疾病 (OGID) 和功能性胃肠道疾病 (FGID) 仍然是一个临床挑战.
- 便calprotectin (FCP) 已经成为一种潜在的非侵入性生物标志物.
研究的目的:
- 评估便calprotectin (FCP) 的诊断实用性,用于识别有机胃肠道疾病 (OGID).
- 评估FCP在区分OGID和功能性胃肠道疾病 (FGID) 的有效性,在患有下胃肠道症状的患者中.
- 审查FCP在各种临床环境和年龄组的诊断准确性.
主要方法:
- 对2013年1月至2022年12月期间发表的研究进行系统审查.
- 搜索了PubMed,Cochrane和Scopus数据库,查找关于FCP的临床诊断研究.
- 包括使用FCP作为指数测试与参考标准 (如结肠镜检查) 相比的研究,使用修订后的QUADAS工具进行质量评估.
主要成果:
- 在从545篇文章的初始搜索中进行了定性综合后,包括了20篇文章.
- 15项研究使用FCP专注于区分炎症性肠病 (IBD) 和刺激性肠综合征 (IBS).
- 该审查证实了在不同患者群体中对OGID进行非侵入性FCP评估的诊断准确性.
结论:
- 便calprotectin (FCP) 在识别有机胃肠道疾病 (OGID) 中具有显著的诊断效用.
- FCP作为一个有效的非侵入性查和监测工具,指导进一步调查的需要.
- 使用FCP可以减少对侵入性手术的依赖,改善患者管理和医疗保健效率.
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