一个随机的,双盲的,安慰剂控制的,并行组12周的试点阶段II试验SaiLuoTong (SLT) 对于轻度认知障碍的老年人认知功能
Genevieve Z Steiner-Lim1,2, Alan Bensoussan1, Elana R Andrews-Marney1
1NICM Health Research Institute Western Sydney University Penrith New South Wales Australia.
Alzheimer's & dementia (New York, N. Y.)
|October 13, 2023
概括
在轻度认知障碍 (MCI) 患者中,SaiLuoTong (SLT) 补充改善了记忆和执行功能. 这种天然化合物在老年人中耐受性很好.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 轻度认知障碍 (MCI) 在老年人群中越来越令人担忧.
- 早期干预对于管理认知衰退至关重要.
- 赛卢通 (SLT) 是一种潜在的治疗剂,用于认知支持.
研究的目的:
- 评估SaiLuoTong (SLT) 在改善MCI患者认知功能的有效性.
- 评估目标人群中SLT的安全性和耐受性.
- 为了确定SLT对记忆检索和执行功能的影响.
主要方法:
- 进行了一项随机的,安慰剂控制的试验.
- 60岁及以上患有MCI的社区居民参与者被纳入.
- 参与者每天接受180毫克SLT或安慰剂12周.
主要成果:
- 与安慰剂相比,SLT在记忆测试中显著改善了延迟回忆 (P=0.010).
- 执行功能,特别是切换和对比能力,显示SLT显著改善 (P=0.038,P=0.032).
- 功能活动得分也表明了SLT的好处 (P=0.047).
结论:
- 赛卢通 (SLT) 在支持MCI患者的记忆检索和执行功能方面表现出有效性.
- 对于患有MCI的老年人 (≥60岁) 来说,SLT耐受性良好,安全.
- 这项研究强调了SLT作为MCI认知健康的辅助疗法的潜力.
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