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Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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Updated: Jul 13, 2025

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

骨瘤工程中的生物力学方面

Ksenia Menshikh¹, Ivana Banicevic², Bojana Obradovic²

¹Center for Translational Research on Autoimmune and Allergic Diseases, Università del Piemonte Orientale, Novara, Italy.

Tissue engineering. Part B, Reviews

|October 13, 2023

概括

本综述考察了骨髓瘤工程中的生物机械刺激. 它评估了当前的3D体外模型是否能够充分弥合与体内条件的差距,以实现强大的癌症药物开发.

科学领域:

生物医学工程生物医学工程
在瘤学瘤学.
生物物理学的生物物理.

背景情况:

抗癌药物开发需要先进的瘤工程模型.
在体外模拟瘤微环境,特别是对于骨髓瘤,仍然具有挑战性.
生物机械刺激越来越被认为是影响瘤行为和药物反应的关键因素.

研究的目的:

审查和评估关于生物机械刺激的骨髓瘤工程中的"体内-体外"差距.
将本地瘤环境中的生物机械线索与工程3D体外模型中的生物机械线索进行比较.
从生物物理角度评估骨瘤工程的现状.

主要方法:

文献综述专注于骨髓瘤中的生物机械刺激.
在体内生物机械线索与工程3D体内模型中的生物机械线索的比较.
分析生物力学在瘤攻击性和化学敏感性中的作用.

主要成果:

在体内生物机械条件与当前体内骨髓瘤3D模型之间存在显著差异.
工程模型越来越多地结合了生物机械刺激,以更好地模仿瘤微环境.
生物力学因素显然影响骨髓瘤细胞的行为和对抗癌药物的反应.

关键词:

在体外3D模型中的3D模型.骨癌骨癌是一种骨癌.骨瘤的微环境骨瘤的微环境骨质肉瘤是骨质肉瘤的一种疾病.

更多相关视频

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

相关实验视频

Last Updated: Jul 13, 2025

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

结论:

弥合骨髓瘤工程中的"体内-体外"差距,需要更多地关注生物机械刺激.
结合生物力学的先进的3D体外模型对于准确的药物测试和理解瘤进展至关重要.
本综述强调了改善骨瘤工程模型所必需的关键生物物理因素.