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慢性全闭并不是成功进行皮肤冠状动脉干预的患者死亡的危险因素:一个队列研究
Emil N Holck1,2, Naja S Winther1,2, Lone Juul-Hune Mogensen1,2
1Department of Cardiology Aarhus University Hospital Aarhus Denmark.
Journal of the American Heart Association
|October 13, 2023
概括
慢性全闭性冠状动脉透皮干预 (CTO PCI) 在成功时显示与非CTO PCI相似的长期死亡率. 然而,不成功的CTO PCI与显著更高的长期死亡率有关.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 公共卫生 公共卫生
背景情况:
- 15%的冠状动脉疾病 (CAD) 患者患有慢性全闭症 (CTO).
- 在皮革冠状动脉干预 (PCI) 中,CTO 构成了挑战.
- 与非CTO PCI相比,CTO PCI的长期结果需要进一步调查.
研究的目的:
- 为了比较成功和失败的CTO PCI的长期预后与非CTO病变的PCI.
- 评估CTO再血管化的对所有原因死亡率的影响.
主要方法:
- 一个观察性的,全区域范围的,基于登记的队列研究.
- 包括从2009年到2019年在丹麦接受PCI的患者.
- 将患者分为非CTO,成功的CTO PCI和失败的CTO PCI组.
- 主要终点:全因死亡率,追踪至2022年1月1日.
主要成果:
- 在21,141名患者中,2108人接受了CTO PCI.
- 与非CTO PCI相比,CTO PCI后的长期全因死亡率较高,但在调整后没有统计学意义.
- 成功的CTO PCI与非CTO PCI相比,死亡率没有差异 (调整后HR为0.99).
- 不成功的CTO PCI与显著更高的长期死亡率有关 (调整HR,1.35).
结论:
- 对CTO进行PCI的患者的长期死亡风险高于没有CTO的患者.
- 成功的CTO PCI与与非CTO PCI相比的长期死亡率有关.
- 失败的CTO PCI显著增加了长期死亡率,突出了需要高成功率的专业CTO计划.
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