非精神活性植物性大麻素抑制人类冠状动脉平滑肌肉和内皮细胞的与炎症相关的变化
Elisa Teichmann1, Elane Blessing1, Burkhard Hinz1
1Institute of Pharmacology and Toxicology, Rostock University Medical Center, Schillingallee 70, 18057 Rostock, Germany.
Cells
|October 13, 2023
概括
非精神活性大麻素大麻 (CBD) 和四大麻 (THCV) 显示出治疗动脉样硬化的潜力. 这些化合物减少了冠状动脉细胞中的细胞增殖和迁移,提供了新的治疗途径.
科学领域:
- 心血管研究研究心血管研究
- 药理学 药理学是指药理学的学科.
- 细胞生物学 细胞生物学
背景情况:
- 动脉样硬化涉及血管光滑肌肉细胞增殖,炎症和白细胞粘附.
- 大麻素已经证明了心脏保护作用,促使对其治疗潜力的研究.
研究的目的:
- 研究大麻 (CBD) 和四大麻 (THCV) 对人类冠状动脉光滑肌细胞 (HCASMC) 和人类冠状动脉内皮细胞 (HCAEC) 的影响.
- 评估CBD和THCV对动脉样硬化相关的增殖,迁移和炎症标志物的影响.
主要方法:
- 评估了CBD和THCV对血小板衍生生长因子刺激的HCASMC增殖和迁移的影响.
- 检查了CBD和THCV对交白素 (IL) -1β和脂多糖 (LPS) 刺激的HCAEC炎症标记物的影响,包括VCAM-1表达.
- 研究了大麻素受体,活性氧物种,p38 MAPK,HDAC和NF-κB通路的作用.
主要成果:
- 在无毒度下,CBD和THCV抑制了HCASMC的扩散和迁移.
- 这两种大麻素都减少了HCAEC中的VCAM-1表达,独立于经典的大麻素受体.
- 在LPS刺激的HCAEC中,CBD和THCV调节了NF-κB调节器,但没有显著地消除单细胞粘附.
结论:
- 非精神活性大麻素CBD和THCV在血管细胞中表现出抗炎和抗增殖作用.
- 这些发现表明,CBD和THCV在治疗动脉样硬化方面有潜在的治疗应用.
- 进一步的临床前研究可以探索CBD和THCV在冠状动脉干预的药物释放支架中.
关键词:
在Cannabidiol中使用.它们是内皮细胞的内皮细胞.基因组脱乙酶 (Histone deacetylases) 是一种人类冠状动脉的人类冠状动脉核因子 κB 核因子 κB顺肌细胞是平滑肌肉的细胞.大麻四水化合物 (tetrahydrocannabivarin) 已经成为一种药物.血管细胞粘附分子-1-1更多相关视频
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