适度运动训练对癌症引起的肌肉损耗的影响
Ana Cristina Corrêa Figueira1,2, Ana Pereira1,2, Luís Leitão1,2
1Sciences and Technology Department, Superior School of Education of Polytechnic Institute of Setubal, 2910-761 Setúbal, Portugal.
Healthcare (Basel, Switzerland)
|October 13, 2023
概括
癌症引起的肌肉衰竭显著影响特定的肌肉,如胃半腹肌. 长期的运动训练有效地预防了瘤动物的肌肉功能障碍.
科学领域:
- 在瘤学瘤学.
- 运动生理学 运动生理学
- 肌肉生物学 肌肉生物学
背景情况:
- 肌肉衰竭 (缩) 是癌症患者经常出现的并发症.
- 运动训练显示出减轻与癌症相关的肌肉损失的潜力.
- 了解对不同类型肌肉的具体影响至关重要.
研究的目的:
- 在两个不同的肌肉表型中量化癌症诱导的肌肉消耗的攻击性.
- 评估耐力运动训练在预防癌症相关肌肉功能障碍方面的有效性.
主要方法:
- 一个由1-甲基-1-氨酸尿素 (MNU) 诱导的乳腺癌的小鼠模型.
- 动物被分为四组:静止瘤携带,运动瘤携带,静止控制和运动控制.
- 经过35周的耐力训练后,对胃骨和肌底肌肉进行了形态测量分析.
主要成果:
- 静止性瘤携带的老鼠显示肌肉横截面积显著减少,无论是胃角肌还是肌底肌.
- 胃半腹肌显示间歇性纤维化增加和从较大的纤维转向较小的纤维.
- 运动训练成功地预防了这些与癌症相关的肌肉消耗效应.
结论:
- 癌症引起的肌肉衰竭不成比例地影响特定的肌肉,特别是胃半中快速缩的糖溶性纤维.
- 胃肌肌肉表现出明显的缩和纤维化,而肌肌则表现出不那么严重的缩.
- 耐力训练是一种有效的对抗癌症相关肌肉损耗的措施.
更多相关视频
06:59A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice
Published on: April 28, 2022
3.6K
12:59Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
12.6K
相关概念视频
Exercise and Muscle Performance
1.5K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.5K
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Exercise and Cardiovascular Response
835
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
835
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Adaptive Mechanisms in Cancer Cells
5.8K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.8K
Exercise and Cardiac Output
1.1K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
1.1K
