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代谢综合征,MASLD和动脉硬化之间的相互作用:一个单一中心的横截面研究

Adelaida Solomon^1,2, Mihai Octavian Negrea^1,2, Călin Remus Cipăian^1,2

¹Faculty of Medicine, "Lucian Blaga" University, 550024 Sibiu, Romania.

Healthcare (Basel, Switzerland)

|October 13, 2023

概括

与代谢相关的脂肪性肝病 (MASLD) 和代谢综合征 (MetS) 相关,MetS患者表现出更大的肝脏和动脉硬性. 一项研究发现,一群患有高脂肪和硬度的群体也有高的MetS流行率,这表明综合诊断.

科学领域:

肝病学肝病学是一种肝病学.
心脏病学心脏病学
代谢疾病代谢疾病

背景情况:

代谢相关的脂肪性肝病 (MASLD),以前称为NAFLD,是慢性肝病的主要原因.
MASLD越来越多地与动脉样硬化血管疾病有关,与代谢综合征 (MetS) 共享风险因素.
患有MASLD的患者往往存在MetS风险因素,动脉样硬化和动脉硬.

研究的目的:

调查代谢综合征患者肝脏干扰和动脉硬之间的关系.
探索MetS成分,肝硬化和动脉硬之间的相互作用.

主要方法:

招募了75名疑似患有MASLD或心脏代谢风险因素的患者.
使用临床评估,实验室测试,超声波 (腹部和带),振动控制的短暂弹性图像 (VCTE/FibroScan) 和动脉图.
应用了两步集群算法来分析患者数据.

主要成果:

患有MetS的患者 (n=26) 显示肝脏参与率 (HSI,FIB4,APRI,VCTE) 和血管疾病 (动脉硬,CIMT) 显著增加.
聚类发现了三个不同的患者群体.
一个肝硬化和动脉硬度升高的群体也患有MetS及其组件的患病率最高.

结论:

代谢综合征与增加的肝硬化和动脉硬性密切相关.
一个独特的患者亚组表现出高脂肪酸,动脉硬和MetS的综合特征.
建议对疑似MetS或MASLD的患者进行全面的诊断策略.

关键词:

动脉硬性动脉硬性动脉样硬化动脉样硬化集群分析集群分析集群分析肝脏硬肝脏硬肝脏硬代谢综合征代谢综合征与代谢相关的脂肪性肝病.非侵入性测试是一种非侵入性测试.脉冲波的速度是脉冲波的速度.振动控制的短暂弹性图形.

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