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Updated: Jul 13, 2025

G Protein-selective GPCR Conformations Measured Using FRET Sensors in a Live Cell Suspension Fluorometer Assay
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可调节的体类化蛋白传感器的工程

Fanny Broch1, Lina El Hajji1, Nicolas Pietrancosta1,2

  • 1Sorbonne Université, École Normale Supérieure, Université PSL, CNRS, Laboratoire des Biomolécules, LBM, 75005 Paris, France.

ACS sensors
|October 13, 2023
PubMed
概括

研究人员通过将传感器与FAST (光激活和吸收转移标签) 系统集成,开发了新的光学蛋白质传感器. 这一创新使得可调节的,通过素结合的全质调制来实现对分析剂有反应的生物传感器.

关键词:
全osteric 蛋白质传感器分析器的传感感知觉.化学遗传的光记者这些光学传感器是光学传感器.

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Allosteric Regulation01:08

Allosteric Regulation

Allosteric regulation of enzymes occurs when the binding of an effector molecule to a site that is different from the active site causes a change in the enzymatic activity. This alternate site is called an allosteric site, and an enzyme can contain more than one of these sites. Allosteric regulation can either be positive or negative, resulting in an increase or decrease in enzyme activity. Most enzymes that display allosteric regulation are metabolic enzymes involved in the degradation or...
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