星球细胞的功能及其在神经疾病中的作用
Wen-Qin Yuan1, Wei-Peng Huang2,3, Yang-Chao Jiang1
1College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang, China.
The European journal of neuroscience
|October 13, 2023
概括
星球细胞对大脑健康至关重要,支持神经元并影响中枢神经系统 (CNS) 疾病. 准星细胞功能为阿尔茨海默氏症和帕金森病等神经系统疾病提供了新的治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 神经学 神经学
背景情况:
- 天体细胞,曾经仅被视为神经元支架,现在被认为具有多种功能,包括结构支持,能量代谢和突触调节.
- 这些功能凸显了星体细胞在维持中枢神经系统 (CNS) 健康和疾病发病过程中的关键作用.
研究的目的:
- 审查星体细胞的结构和功能.
- 探索星球细胞和各种中枢神经系统疾病之间的复杂关系.
- 讨论用于神经保护和功能恢复的星细胞向药物治疗方法.
主要方法:
- 文献综述专注于天体细胞生物学.
- 分析星细胞参与特定中枢神经系统疾病 (NMO,MS,AD,PD,亨廷顿病) 的分析.
- 检查针对天体细胞通路和分子的治疗策略.
主要成果:
- 天星细胞积极影响突触形成,功能和消除.
- 星细胞因子,受体,通道和通路的调节失调与中枢神经系统疾病有关.
- 特定的天体细胞分子,如水素4和连素43,在NMO,AD和中风中发挥着不同的作用.
结论:
- 调节星细胞功能为中枢神经系统疾病提供了一个有希望的治疗途径.
- 向星球细胞可以抑制疾病的进展,并促进神经元的恢复.
- 对天体细胞特异性机制的进一步研究可能会产生新的神经保护药物.
相关概念视频
Glial Cells
87.4K
Overview
87.4K
Nervous Tissue: Glial Cells
3.1K
Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
3.1K
Neuron Structure
13.0K
Neurons are the main type of cell in the nervous system that generate and transmit electrochemical signals. They primarily communicate with each other using neurotransmitters at specific junctions called synapses. Neurons come in many shapes that often relate to their function, but most share three main structures: an axon and dendrites that extend out from a cell body.
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
13.0K
The Blood-brain Barrier
47.5K
Overview
47.5K
Disorders of the Nervous Tissue
1.4K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.4K
Role of Neurotransmitters in Memory
592
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
592


