在女性和男性中使用完全磁 levitated 左心室辅助装置的临床结果
Bhavadharini Ramu1, Rebecca Cogswell1, Ashwin K Ravichandran2
1University of Minnesota, Minneapolis, Minnesota, USA.
JACC. Heart failure
|October 13, 2023
概括
接受HeartMate3左心室辅助装置 (LVAD) 的女性的结果与男性相似,但年轻女性的中风,出血和感染率较高. 需要进一步的研究来了解这些差异在先进的心力衰竭治疗.
科学领域:
- 心血管医学 心血管医学
- 医疗器械 医疗器械
- 心脏衰竭管理的管理
背景情况:
- 左心室辅助器件 (LVAD) 对晚期心力衰竭至关重要,但它们在女性中的使用仍然不够理想.
- 了解当代LVADs的性别差异对公平护理至关重要.
研究的目的:
- 为了比较接受HeartMate 3 (HM3) LVADs的女性和男性之间的特征和2年结果.
- 分析性别之间的不良事件的差异,包括中风,出血和感染.
主要方法:
- 从MOMENTUM 3研究中分析了2200名接受HM3 LVADs的患者.
- 在女性和男性之间比较没有致残性中风或功能故障的2年存活率.
- 评估整体存活率,不良事件和功能状态.
主要成果:
- 女性 (20.4%) 较年轻,患有非缺血性心肌病,与男性相比更常见的黑人.
- 在女性和男性的初级复合终点或2年总生存期中没有发现显著差异.
- 女性患中风,严重出血和感染的几率更高,尤其是年轻女性,尽管这些情况在老年患者 (>65岁) 中没有观察到.
- 两性都在6分钟的步行距离和生活质量方面表现出类似的改善.
结论:
- 当代完全磁悬浮的LVAD显示,女性和男性在2年后的生存和功能结果相似.
- 年轻女性中血红相容性相关事件和感染率的增加需要进一步调查.
- 这些发现突显出需要探索观察到的事件差异的潜在原因,以优化所有患者的LVAD治疗.
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