骨肌肉质量的相关值和近期发病糖尿病中新型亚型之间的差异
Christian Herder1,2,3, Haifa Maalmi1,2, Nina Saatmann1,2
1Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf 40225, Germany.
The Journal of clinical endocrinology and metabolism
|October 13, 2023
概括
骨肌肉质量 (SMM) 在新型糖尿病中有所不同,主要受到临床因素的影响,而不是炎症生物标志物. 了解这些差异是管理糖尿病进展的关键.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 糖尿病研究 糖尿病研究
背景情况:
- 低骨肌量 (SMM) 与长期存在的糖尿病有关.
- 关于新诊断糖尿病的个体中SMM的数据有限.
研究的目的:
- 确定最近发病的糖尿病中与SMM相关的因素.
- 在新型糖尿病亚型中比较SMM水平.
主要方法:
- 在842名近期糖尿病患者 (德国糖尿病研究) 中,分析的SMM正常化为体重指数 (SMM/BMI).
- 评估了临床变量,79个炎症生物标志物和SMM/BMI之间的关联.
- 通过调整的分析,在糖尿病亚型中比较SMM/BMI.
主要成果:
- 男性的性别和身体活动与SMM/BMI正相关.
- 年龄,BMI,HbA1c,HOMA-β和eGFR与SMM/BMI相反相关.
- 糖尿病亚型 (严重的自身免疫与严重的胰岛素抵抗/轻度肥胖相关) 之间SMM/BMI有所不同,但在调整后差异减少.
结论:
- 在糖尿病亚型之间,SMM/BMI的差异很大,可能会影响疾病的进展.
- 临床变量,而不是炎症生物标志物,主要解释SMM/BMI的变化.
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