ADCdb:抗体与药物结合物的数据库
Liteng Shen1,2,3,4, Xiuna Sun1,5, Zhen Chen1
1College of Pharmaceutical Sciences, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou 310058, China.
Nucleic acids research
|October 13, 2023
概括
一个新的数据库,ADCdb,已经开发,以巩固关键的药物和生物活性数据的抗体药物合物 (ADCs). 该资源通过提供有关这些创新生物制药药物的全面信息,有助于设计更有效的ADC.
科学领域:
- 生物制药药物开发 生物制药药物开发
- 计算生物学 计算生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗体-药物合物 (ADC) 是先进的生物制药,通过单克隆抗体 (mAbs) 向疾病部位传递强大的有效载荷,从而提高治疗效率并降低毒性.
- 设计有效的ADC需要全面的药物和生物活性数据,目前缺乏集中存储库.
研究的目的:
- 开发ADCdb,一个新的数据库,整合ADCs的各种信息.
- 从多个角度为ADC提供关键的药物信息和生物活性数据.
主要方法:
- 收集了6572个ADC的数据,包括已批准的,临床试验,临床前,体内和细胞系/标测试数据.
- 从临床试验和异种移植模型等各种来源提取并编制了9171个文献报告的活动.
- 开发了ADCdb数据库,使这些信息公开可访问.
主要成果:
- ADCdb包含了6572个ADC的详细药物信息.
- 该数据库包括来自不同实验环境的9171个报告的生物活动.
- 收集的数据涵盖了批准的药物,临床试验,临床前研究和体外/体外测试.
结论:
- ADCdb是生物制药药物发现研究人员的宝贵资源.
- 该数据库有助于设计和开发新型抗体-药物联合体.
- 预计ADCdb的公共可访问性将促进各个研究领域的广泛兴趣和合作.
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