对甲状腺激素的敏感性受损与甲状腺细胞群中维生素D水平降低有关
Yuanmeng Li1,2, Juan Sun2,3, Yang Jiao2,4
1Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
The Journal of clinical endocrinology and metabolism
|October 13, 2023
概括
甲状腺激素敏感性受损与乙甲状腺患者的维生素D水平降低有关. 这种关联因年龄,性别,种族和体重指数 (BMI) 而有很大差异.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 维生素D与甲状腺功能之间的关系尚未得到充分证实,对维生素D对甲状腺激素敏感性的影响的研究有限.
- 现有研究表明,关于维生素D和甲状腺特征的结果是相互矛盾的,需要进一步调查.
研究的目的:
- 为了研究维生素D水平与甲状腺激素敏感性之间的相关性.
- 探索年龄,性别,种族和BMI等因素如何影响这种关系.
主要方法:
- 分析了从6452 euthyroid参与者在国家健康和营养检查调查 (2007-2012) 的数据.
- 使用基于量子的甲状腺反指数 (TFQI),TSH指数 (TSHI) 和甲状腺激素耐药性指数 (TT4RI) 测量甲状腺激素敏感性.
- 评估25-基维生素D [25(OH) D]水平,并为混变量进行调整.
主要成果:
- 甲状腺激素敏感性受损与25~OH) D水平降低有关 (P<0.05对于TFQI和TT4RI).
- 年龄特定的分析显示,年轻人 (20-60岁) 呈负相关性,老年人 (60-80岁) 呈正相关性.
- 观察到性别特异性差异,在不同种族和BMI类别中观察到复杂的非线性关系.
结论:
- 维生素D水平的降低与甲状腺激素敏感性受损的人相关.
- 维生素D与甲状腺激素敏感性之间的关联是由年龄,性别,种族和体重指数调节的.
- 需要进一步的研究来阐明这些复杂相互作用背后的机制.
相关概念视频
01:20Synthesis and Regulation of Thyroid Hormones
4.7K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.7K
01:18Functions of Thyroid Hormones
2.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.8K
01:23Role of Skin in Vitamin D Synthesis
5.2K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.2K
01:30Vitamins
746
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
746
01:17Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
01:25Role of Vitamins in Maintaining Bone Health
3.4K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.4K