相关实验视频
Updated: Jul 13, 2025
08:03
In Vitro Model of Coronary Angiogenesis
Published on: March 10, 2020
7.8K
VEGF-A诱导的远端外流通道结构和功能的变化
Jannis Oltmann1, Mark Morell1, Mohamad Dakroub1
1Department of Ophthalmology, University Hospital Würzburg, Josef-Schneider-Straße 11, 97080, Würzburg, Germany.
概括
血管内皮生长因子-A (VEGF-A) 扩展远部外流管道血管,增强液体外流设施. 这种效应独立于状眼网 (TM) 发生,这表明了一种新的青光眼调节途径.
科学领域:
- 眼科医生 眼科 眼科
- 血管生物学 血管生物学
- 玻璃眼研究研究 玻璃眼研究
背景情况:
- 远端外流通道对于维持眼内压力 (IOP) 是至关重要的.
- 血管内皮生长因子-A (VEGF-A) 在血管化和组织重塑中起作用.
- 了解VEGF-A对眼睛外流的影响对于玻璃眼瘤治疗策略至关重要.
研究的目的:
- 研究VEGF-A对远端外流管道血管的影响.
- 为了确定VEGF-A诱导的变化如何影响眼液外流设施.
主要方法:
- 用VEGF-A perfused的猪前部细分被与对照组进行了比较.
- 光谱域光学连贯性断层扫描 (SD-OCT) 用于3小时内3D成像流出管道容器体积变化.
- 眼内压力 (IOP) 和外流装置在48小时内测量,以响应VEGF-A.
主要成果:
- 在100分钟内,VEGF-A显著增加了远端外流管血管体积的16.8%.
- 在24小时内,VEGF-A在眼睛中增强了38.6%的外流设施,没有状眼网 (TM).
- 对照眼没有显示出船舶体积或流出设施的显著变化.
结论:
- VEGF-A在远端外流通道中引起血管扩张.
- VEGF-A增加了外流能力,这种效果独立于带状网状网.
- 这些发现表明,与远端外流调节相关的绿眼的潜在治疗标.
相关概念视频
01:24Regulation of Angiogenesis and Blood Supply
2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
01:10Mechanism of Angiogenesis
5.5K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
5.5K