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沉默circSERPINE2通过YBX3/PCNA/p21轴抑制介酶干细胞衰老

Fenglei Chen1, Shan Wang2, Chenying Zeng2

  • 1Department of Orthopedics, Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518033, People's Republic of China.

Cellular and molecular life sciences : CMLS
|October 13, 2023
PubMed
概括

像circSERPINE2这样的循环RNA (circRNAs) 随着年龄的增长而积累. 通过小干扰RNA (siRNA) 准circSERPINE2,可以使细胞间干细胞 (MSC) 恢复青春,并可能治疗诸如骨关节炎之类的衰老疾病.

关键词:
细胞衰老 细胞衰老介质细胞干细胞 介质细胞干细胞骨关节炎是一种骨关节炎.环绕RNAss 的时间.

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