氨基酸酶体过量的顺序扩增由凝聚物和 Racemic 化合物:可信的 益生菌通路 走向同化性
1Department of Physics, Alabama A&M University, Huntsville, AL, 35762, USA. anup.sharma@aamu.edu.
概括
氨基酸可以形成凝聚物和racemic化合物. 在早期地球条件下观察到的这种双结晶行为,解释了同质性如何出现,将反体过量 (EE) 放大到50%.
科学领域:
- 天体生物学 天体生物学
- 地质化学 地质化学
- 晶体学 晶体学是指结晶学.
背景情况:
- 氨基酸表现出双重结晶行为:形成凝聚物和种族化合物.
- 益生菌条件可能涉及到连续结晶过程,影响分子同质性.
- 对于生命起源研究来说,了解反体过量 (EE) 放大是至关重要的.
研究的目的:
- 量化分析氨基酸的顺序结晶如何产生同质性.
- 通过聚合物和赛米化合物系统来研究反体过量 (EE) 的放大.
- 模拟在前生物环境中产生显著的EE所需的条件.
主要方法:
- 利用阿斯巴拉提酸作为定量分析的模型系统.
- 采用三元相位图来确定相位行为和超和值.
- 导出了EE放大依赖超和和eutectic可溶性的数学关系.
主要成果:
- 在聚合物系统 (CS) 中,至少需要1.65的超和,才能在种族化合物系统 (RCS) 中达到50%的最大EE.
- 在切换到RCS之前,在CS中优先结晶 (PC) 的计算值对比 (EE) 值.
- 证明了顺序放大:在CS中接近零的EE,在RCS中约为50%的EE.
结论:
- 氨基酸在凝聚物和血化合物系统中的顺序结晶提供了一个可行的 prebiotika机制来产生同化性.
- 这种双重系统有效地放大了等离子过量 (EE),为生物系统中观察到的奇拉纯度提供了途径.
- 该研究提供了对同化性出现所必需的物理化学条件的定量见解.
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