隔膜肌的功能在期限和早产婴儿
Sotirios Fouzas1, Aggeliki Vervenioti1, Asimina Tsintoni1
1Neonatal Intensive Care Unit, Department of Paediatrics, University of Patras School of Medicine, Rio, Patras, 26500, Greece.
European journal of pediatrics
|October 13, 2023
概括
过早出生的婴儿表现出膜强度和耐力降低,增加疲劳风险. 支气管肺功能障碍症 (BPD) 在非常早产的婴儿中可以进一步损害腹膜功能.
科学领域:
- 新生儿生理学 新生儿生理学
- 呼吸系统医学 呼吸系统医学
- 儿科肺病学 儿科肺病学
背景情况:
- 隔膜管理呼吸工作的能力在早产婴儿中是有限的.
- 隔膜功能,最大跨隔膜压力 (Pdimax) 和压力-时间指数 (PTIdi) 的关键指标在婴儿中尚未得到充分研究.
研究的目的:
- 为了确定影响隔膜功能的因素,在期限和早产婴儿.
- 为了比较预产和早产婴儿之间的隔膜强度和耐力,有和没有支气管肺功能障碍 (BPD).
主要方法:
- 使用Pdimax (强度) 和PTIdi (负载与容量比) 评估149名婴儿 (56名,93名早产) 的隔膜功能.
- 术后婴儿和早产婴儿之间的比较测量,以及带有BPD和没有BPD的早产婴儿之间的比较测量.
- 分析了妊娠年龄 (GA) 和通风/氧气支持的持续时间作为预测因素.
主要成果:
- 满期婴儿比没有BPD的早产婴儿具有更高的Pdimax和更低的PTIdi.
- 在没有BPD的婴儿中,GA是Pdimax和PTIdi的主要预测因素.
- 在非常早产婴儿 (GA < 32 周) 中,患有 BPD 的婴儿与没有 BPD 的婴儿相比,显著降低了 Pdimax 和提高了 PTIdi.
结论:
- 过早出生的婴儿的隔膜强度和耐力下降,使他们容易疲劳.
- 支气管肺功能障碍 (BPD) 可能会加剧在非常早产婴儿中缺陷的隔膜功能.
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