特拉马多尔诱导了老鼠状的亡,炎症和氧化应激
Maryam Mehranpour1, Meysam Hassani Moghaddam2, Mohammad-Amin Abdollahifar3
1Department of Genetics, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran.
Metabolic brain disease
|October 13, 2023
概括
特拉马多尔暴露会增加胆管 (CP) 体积和炎症基因表达,导致神经毒性. 这项研究揭示了特拉马多尔.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
背景情况:
- 冠状腺 (CP) 产生脑脊液 (CSF) 和对大脑功能至关重要的神经营养因子.
- 特拉马多尔是一种止痛药,可以引起诸如焦虑和情绪不稳定等副作用.
研究的目的:
- 为了研究慢性特拉马多尔暴露对胆脉 (CP) 的影响.
- 为了评估特拉马多尔后的CP炎症和亡基因表达的变化.
主要方法:
- 鼠每天接受特拉马多尔 (50毫克/公斤) 三周.
- 脑脊液 (CSF) 被收集来测量超氧化物脱酶 (SOD) 和谷氨酸 (GSH).
- 立体分析评估了CP体积,细胞数,毛细血管数和线粒体形态.
主要成果:
- 特拉马多尔降低了CSF中的SOD和GSH水平,表明氧化应激.
- CP体积,上皮细胞和毛细血管显著增加.
- 在CP中观察到炎症和亡基因的升级.
结论:
- 特拉马多尔诱导神经毒性在冠状动脉.
- 亡,炎症和氧化应激是特拉马多尔诱导的CP神经毒性的关键机制.
相关概念视频
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...