对与急性和康复性感染相关的炎症进行蛋白质组分析
Tara K Sigdel1, Swastika Sur1, Patrick Boada1
1Division of Multi-Organ Transplantation, Department of Surgery, University of California San Francisco, 513 Parnassus Ave, Med Sciences Bldg, Room S1268, San Francisco, CA, 94143, USA.
Inflammation
|October 13, 2023
概括
传染病具有共同的免疫信号,揭示了病毒和细菌等各种病原体的普遍炎症反应. 这些发现突出了共同的分子实体,尽管有独特的疾病特征.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 系统生物学 系统生物学
背景情况:
- 传染病对全球健康构成了重大挑战.
- 了解病原体特异性与常见免疫反应的区别对于开发有效的治疗方法至关重要.
- 以前的研究还没有完全阐明不同类型感染的共享免疫特征.
研究的目的:
- 识别疾病特异性和常见的免疫特征,以应对各种病原体.
- 调查不同病原体是否引起与治疗干预相关的共享分子反应.
- 在多种传染病中分析急性感染和康复期间的免疫特征.
主要方法:
- 对患有莱姆病,结核病,疟疾,登革热病毒,西尼罗河病毒,细胞巨型病毒和多重病毒感染的患者的血液样本进行分析.
- 利用基于抗体的测定方法量化了大约350种细胞表面标记物,细胞因子和化学因子.
- 在急性感染和康复阶段的免疫特征与健康的捐献者血液进行比较.
主要成果:
- 鉴定出特定于感染急性阶段的独特蛋白质特征,在康复期间发生变化.
- 与健康对照人群相比,在所有病原体类型中观察到瘤亡因子受体超级家族成员6 (TNR6),CC-C动机化学因子受体7 (CCR7) 和CC-C动机化学因子连接体-1 (CCL1) 的水平增加.
- 在常见的生物途径中发现了蛋白质的丰富,包括细胞表面受体信号传递和对外部刺激的反应,无论病原体类型如何.
结论:
- 在各种传染病体中证明了常见的免疫调节和促炎信号的存在.
- 突出显示共享的分子通路和标记,无论病原体是病毒,细菌还是原生动物,都会被激活.
- 暗示了针对这些常见途径的广泛适用的免疫调节治疗策略的潜力.
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