相关实验视频

Updated: Jul 13, 2025

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

Published on: October 19, 2014

在初级中枢神经系统淋巴瘤中,剩余扩散权重成像高强度信号可以预测早期复发

Shumpei Onishi¹, Fumiyuki Yamasaki², Vishwa Jeet Amatya³

¹Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Journal of neuro-oncology

|October 13, 2023

概括

扩散权重成像 (DWI) 可以预测初级中枢神经系统淋巴瘤 (PCNSL) 患者的复发. 治疗后残留的DWI高强度信号表明较短的无进展生存期,这表明其在评估PCNSL治疗有效性的价值.

科学领域:

神经辐射学神经辐射学
在瘤学瘤学.
医疗成像医学成像

背景情况:

主要中枢神经系统淋巴瘤 (PCNSLs) 通常使用后对比T1加权成像 (T1WI) 进行评估.
对T1WI的不完全增强可能表明残留瘤,需要改进评估治疗反应的方法.
扩散权重成像 (DWI) 正在探索其在PCNSL患者中预测复发的潜力,这些患者达到完全响应 (CR) /未确认的CR (CRu).

研究的目的:

评估扩散加权成像 (DWI) 在预测中枢神经系统原发性淋巴瘤 (PCNSL) 患者中复发的实用性.
确定DWI是否可以提高治疗响应评估的准确性,超出传统的T1WI.

主要方法:

分析了54名获得CR/CRu的PCNSL患者.
患者根据治疗后残留的DWI高强度信号的存在或不存在来分组.
卡普兰-梅尔分析用于评估整体存活率 (OS) 和无进展存活率 (PFS).

主要成果:

在18名患者中观察到残留的DWI高强度信号.
R-MPV疗法与剩余DWI高强度信号的发病率较低有关 (p=0.0453).
剩余DWI高强度信号的患者的PFS中位数显著较短 (14.0个月与85.1个月,p<0.0001).

结论:

治疗后的残留DWI高强度信号与PCNSL中较短的无进展生存时间有关.
DWI作为一个有价值的补充成像序列,用于预测PCNSL患者在T1WI上CR/CRu的早期复发.

关键词:

扩散权重图像扩散权重图像扩散权重图像淋巴瘤是一种淋巴瘤.主要中枢神经系统淋巴瘤

更多相关视频

Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations

Glioblastoma Relapse Post-Resection Model for Therapeutic Hydrogel Investigations

Published on: February 24, 2023

Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy

Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy

Published on: May 22, 2020

相关概念视频

Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...