空气污染和过敏性鼻炎:来自前性队列研究的发现
Peiyang Luo1, Jiacheng Ying1, Jiayu Li2
1The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Environmental science & technology
|October 13, 2023
概括
长期暴露于空气污染,包括PM2.5和NO2,显著增加患过敏性鼻炎 (AR) 的风险. 具有高遗传倾向的个体面临更大的风险,突出需要改善空气质量.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 遗传学 遗传学 是一个
背景情况:
- 过敏性鼻炎 (AR) 是一种普遍存在的疾病,具有重大公共卫生影响.
- 了解导致AR风险的环境和遗传因素对于预防和管理至关重要.
研究的目的:
- 研究长期暴露于环境空气污染和患过敏性鼻炎 (AR) 的风险之间的关联.
- 探索空气污染暴露和遗传倾向对AR风险的综合影响.
主要方法:
- 对379,488名最初没有AR的英国生物库参与者的纵向分析.
- 使用土地利用回归模型估计每年PM2.5,PM粗,PM10,NO2和NO的平均度.
- 考克斯的比例危险模型和加权的多基因风险评分被用于评估风险和遗传影响.
主要成果:
- 在增加AR风险和暴露于PM2.5,PM粗,PM10,NO2和NO之间发现了显著的关联.
- 这些污染物的较高度与AR发展的高危险比率相关.
- 在高空气污染暴露和高遗传风险的参与者中观察到AR风险最高,尽管没有发现显著的相互作用.
结论:
- 长期暴露于环境空气污染物与过敏性鼻炎的风险增加有关.
- 这种风险在具有高度AR遗传倾向的个体中尤为明显.
- 这些发现强调了改善空气质量的必要性,以减轻AR的发生率.
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