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Updated: Jul 13, 2025

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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循环介导激素诱导激活干扰素基因蛋白的刺激器

Rui Li1,2, Lin Chen2, Xinheng He2,3

  • 1School of Pharmacy, China Pharmaceutical University, 639 Longmian Road, Nanjing 211198, China.

Journal of chemical information and modeling
|October 13, 2023
PubMed
概括

分子动力学模拟揭示了STING激动剂如何通过结合STING和TBK1.1来激活免疫反应. 关键的STING区域,特别是环α5,对于这种全激活至关重要,指导未来的癌症药物开发.

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