在韩国肌缩侧面硬化症患者中,母音参数的临床下关节性变化,其声音在感知上正常
Jin-Ah Kim1,2,3, Hayeun Jang4, Yoonji Choi5
1Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea.
PloS one
|October 13, 2023
概括
对韩国肌缩侧面硬化症 (ALS) 患者的母音特性进行定量分析,与对照人群相比,发现了显著的差异. 这些声学测量可以检测早期的泡功能障碍,与疾病严重程度相关.
科学领域:
- 神经学 神经学
- 语音科学 语言科学
- 生物医学工程 生物医学工程
背景情况:
- 在肌缩侧面硬化症 (ALS) 中评估囊泡功能障碍的定量方法有限.
- 早期检测亚临床气囊变化对于管理ALS进展至关重要.
研究的目的:
- 描述韩国ALS患者的母音声学特性.
- 调查母音参数与ALS临床特征之间的关联.
- 为了确定ALS患者与感知正常的声音的亚临床关节变化.
主要方法:
- 对43名ALS患者和20名健康对照进行前性研究.
- 使用Prat软件分析声学参数 (持续时间,F1,F2,VSA,VAI) 的语音样本.
- 通过ALS功能评分尺度修订 (ALSFRS-R) 语音分数进行评估的脱节症.
主要成果:
- 与对照组相比,患有ALS脱发性关节炎的患者表现出明显更长的母音持续时间.
- 音声空间区域 (VSA) 和音声关节指数 (VAI) 在患有脱节症的ALS患者和对照人群之间有显著差异 (AUC=0.912).
- /a/和VSA的F1频率将早期ALS患者与对照患者区分开来 (AUC=0.887);VSA和VAI与ALSFRS-R语音子分数相关.
结论:
- 对母音参数的声学分析,特别是VSA和VAI,为检测ALS的亚临床气囊功能障碍提供了一个敏感的指标.
- 这些参数与疾病严重程度相关,有助于早期诊断和监测ALS进展.
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