氧化应激生物标志物触发多重复合工具用于动脉样硬化的辅助诊断
Yuan Ma1, Wei Sun2,3, Zhifei Ye4
1State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Science advances
|October 13, 2023
概括
这项研究引入了一种新的动脉样硬化诊断工具,可以测量斑块和尿液中的氧化应激标志物. 这种工具有助于评估疾病的进展,并有助于诊断.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 心血管研究研究心血管研究
背景情况:
- 氧化应激对动脉样硬化发展至关重要,但其确切的作用需要进一步阐明.
- 麦隆迪甲基 (MDA) 是氧化应激的一个关键生物标志物,但全面的评估方法是有限的.
研究的目的:
- 开发一种多重诊断工具,用于评估内和尿道甲酸 (MDA).
- 为了使氧化应激在动脉样硬化进展和治疗中的动态监测.
主要方法:
- 设计了一种近红外MDA响应分子 (MRM) 和一种酸解锁的比度光声纳米探针,用于板内MDA检测.
- 适应MRM用于特定的尿路MDA检测.
- 在动脉样硬化小鼠模型和人类队列 (>600名参与者) 中验证了该工具.
主要成果:
- 纳米探测器有效地报告了斑块内MDA,反映了斑块负担.
- 核磁共振检测 (MRM) 显示了尿道MDA检测的高特异性.
- 在健康个体和动脉样硬化患者之间观察到尿中MDA水平的显著差异.
结论:
- 开发的多重复合工具集成了光声成像和尿液分析,用于全面评估氧化应激.
- 这种工具可以动态监测甲状腺内和全身氧化应激,显示了辅助动脉样硬化诊断的前景.
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