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耐酸近红外II Ag2Se量子点用于胃肠道成像

Ling-Ling Yang¹, Wei Zhao², Zhen-Ya Liu²

¹The Institute for Advanced Studies, and College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China.

Analytical chemistry

|October 13, 2023

概括

研究人员开发了稳定,耐酸的银化物 (Ag2Se) 量子点,用于近红外II (NIR-II) 光成像. 这些生物相容的量子点允许清晰的,长期的胃肠道成像和体内疾病诊断.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学成像技术生物医学成像技术

背景情况:

近红外II (NIR-II) 光成像为生物医学应用提供了优势.
由于毒性低和狭窄的带间隙,银化物 (Ag2Se) 量子点 (QD) 是有希望的.
现有的Ag2Se QD在胃肠道 (GI) 成像方面面临挑战,包括消化环境的不稳定性.

研究的目的:

开发一种合成稳定,水中可分散的Ag2Se QDs用于肠道成像的方法.
为了提高Ag2Se QDs的稳定性和抗酸性.
为了评估这些QDs对肠道NIR-II光成像的疗效.

主要方法:

在酸性条件下使用谷氨 (GSH) 持续生产Se前体.
在水中分散的Ag2Se QDs与NIR-II发射 (600-1100 nm) 的合成.
用GSH对Ag2Se QD进行表面被动化,以提高稳定性和抗酸性.

主要成果:

成功合成了具有卓越的合体和光稳定性的NIR-II Ag2Se QDs.
在胃酸中表现出了显著的稳定性,使得长期的实时肠道静脉直立监测成为可能.
与X射线成像相比,实现了细肠结构 (宽度低至1.07毫米) 的更清晰可视化.

结论:

开发了一种用于合成抗酸纳米晶体的新策略.
合成的Ag2Se QDs具有抗酸性,低毒性和生物相容性.
这些QD显示出在体内胃肠道成像和胃肠道疾病诊断方面显著的前景.

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